Megalis presents a replica of brand Cialis, used to treat male impotence diseases. Being a generic version of its branded drug, Megalis is of the same efficiency and power, but its huge advantage is very cheap and affordable price.

It is essential to know when you begin the treatment with Megalis, this medication contains tadalafil as the main ingredient, able to provide hard erections for men for longer time and treat their erectile dysfunction (ED) problems.

It is important to study the mechanism of the medicine’s action before you buy Megalis and begin taking it. During a sexual intercourse under normal circumstances, the penis of a healthy man fills up with blood resulting in an erection.

In case of erectile dysfunction the amount of blood is not enough for causing an erection. In other words, penile erection during sexual intercourse is caused by increased blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This reaction is mediated by the release of nitric oxide from nerve and endothelial cells, which stimulates the synthesis of cGMP (cyclic guanosine monophosphate) in smooth muscle cells. Cyclic GMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.

The blocking of inhibitor (substance decelerating biological processes and chemical reactions) called PDE-5 (phosphodiesterase type 5) enhances erectile function by increasing the amount of cGMP in the male genitals. Thus, tadalafil inhibits this PDE-5 enzyme, providing a long lasting erection and sexual pleasure. However, tadalafil's inhibition of PDE-5 will have no effect without a normal sexual stimulation of the penis or without a natural object of attraction.

However, clinical tests prove that comparing to Viagra and Levitra, Megalis’ effect lasts much longer – up to 48 hours; besides, Megalis has fewer side effects.

You need to take Megalis from 30 minutes to 12 hours before you plan having a sexual intercourse; the effect starts in approximately 30 minutes and lasts for up to 48 hours after taking. 

Undoubtedly, your physician should be informed whether you have any disorders, especially kidney or liver disease, sickle-cell anemia, abnormally high level of lipids in the blood (hyperlipidaemia), diabetes mellitus, ulcer of stomach, hypertension or hypotension, heart failure or heart attack, angina, arrhythmia, coronary artery disorder or penis injury.

The most common side effects of Megalis are headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually disappear in a few hours.

Patients revealing back pain and muscle aches usually experience this condition for 12 to 24 hours after taking Megalis. As a rule back pain and muscle aches usually disappear themselves within 48 hours. Call your doctor if you reveal a side effect bothering you for a long time; in case if you have erection lasting longer than 4 hours, seek for the emergency medical service, as it may permanently damage your penis.